Identity of a newly isolated human polyomavirus from a patient with progressive multifocal leucoencephalopathy.
نویسندگان
چکیده
Isolation of a strain of polyomavirus, designated COL, from the brain of a patient with progressive multifocal leucoencephalopathy is described. The COL strain is antigenically similar to JC polyomavirus, previously isolated from a brain affected by progressive multifocal leucoencephalopathy and is unrelated to BK, another human polyomavirus isolated from urine. Immunological cross testing of viruses in the Polyomavirus genus shows that there are at least six antigenic types in this group.
منابع مشابه
Polyomavirus-Associated Progressive Multifocal Leukoencephalopathy (PML) in HAART era
Polyomaviruses may cause human disease, particularly in immunocompromised hosts. JCV, one of the members of polyomaviridae family, is the causative agent of the neurological disease progressive multifocal leukoencephalopathy (PML), which occurs mostly in immunocompromised patients. Progressive Multifocal leukoencephalopathy (PML) is a progressive demyelinating disorder of the central nervous sy...
متن کاملAdvances in Human Polyomaviruses Field
Up to 2007, two human polyomaviruses BK (BKPyV) and JC (JCPyV) were known and named after the initials of the patients where they were first isolated. BKV was isolated from the urine of a kidney transplant patient affected by urethral stenosis [1]. JCV was identified in the brain tissue of a patient with Hodgkin lymphoma who developed a demyelinating disease known as progressive multifocal leuk...
متن کاملDiagnosis of progressive multifocal leucoencephalopathy by hybridisation techniques.
In situ hybridisation with acetyl-aminofluorene (AAF) and 35S-labelled DNA probes for polyomaviruses, was used to detect JC virus DNA in brain necropsy material in a patient with progressive multifocal leucoencephalopathy (PML). In a second patient PML was diagnosed from a brain necropsy specimen using the same technique. The main infected cell type were oligodendrocytes; dot hybridisation was ...
متن کاملProgressive Multifocal Leucoencephalopathy and Primary Hypersplenism. with a Note on the Association between Disease of the Reticuloendothelial System and Progressive Multifocal Leucoencephalopathy.
A patient with progressive multifocal leucoencephalopathy was found to have primary hypersplenism, a benign disorder of the reticuloendothelial system. He failed to respond to conventional doses of corticosteroids. The clinical and pathological manifestations of his illness are described, and the development of the histopathological changes in the nervous system is discussed. Consideration of a...
متن کاملRemission of progressive multifocal leucoencephalopathy in SLE after treatment with cidofovir: a 4 year follow up.
Progressive multifocal leucoencephalopathy (PML) is an opportunistic infection caused by human polyomaviruses such as the JC virus. It usually occurs as a severe complication of immunosuppression in patients with primary disorders of the immune system or secondary impairment of immune function, for example, after iatrogenic states of immunosuppression. PML usually takes a rapidly progressive co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of clinical pathology
دوره 27 5 شماره
صفحات -
تاریخ انتشار 1974